A patient who is positive for the human immunodeficiency virus (HIV) is diagnosed with a Cryptococcus neoformans infection. The attending resident prescribed Griseofulvin; however, the patient's condition did not seem to improve. Which one of the following statements explains this discrepancy?
a. The dose should be increased to penetrate the blood-brain barrier.
b. Nystatin, which would have been more effective, should have been prescribed.
c. Griseofulvin is not effective against C. neoformans; therefore the therapy should be changed.
d. Potassium iodide is the therapy of choice, not griseofulvin.
C
Fluconazole has excellent activity against most Candida spp. and C. neoformans; therapeutic le-vels are easily reached in the central nervous system. Griseofulvin is an oral agent used to treat dermatophytosis fungal infections; therefore the wrong antifungal was prescribed to this patient.
You might also like to view...
Viroids are:
A. a class of so-called slow viruses. B. proteins that may infect man and other animals causing spongiform encephalopathy. C. a new class of small single stranded DNA viruses that infect some animals. D. short infectious single stranded RNAs that can infect some plants.
Multiple operons may be controlled by ________ or ________.
Fill in the blank(s) with the appropriate word(s).
Two weeks following a hiking trip in which several ticks were noticed and numerous mosquitoes were biting, a 25-year-old man notices a rash shaped like a red ring on the back of his thigh. He was not concerned because he had no other symptoms. Three months later he noticed significant pain in his elbows and his knees. What is the most likely cause of his illness?
A. Ehrlichiosis B. Rocky Mountain Spotted Fever C. West Nile encephalitis D. Lyme disease
________ is the mechanism by which some organisms, such as Komodo dragons, can develop eggs into zygotes without sperm
Fill in the blank with correct word.