Differentiate between the causes of early-onset and late-onset Alzheimer's disease

Question

What will be an ideal response?

Answer 1

Early-onset Alzheimer's disease involves the development of symptoms prior to the age of 60 . It runs in families, and the text identifies an autosomal dominant inheritance pattern, which means that a person with this sort of genetic proclivity has a 100% chance of developing the illness rather than simply being a dormant carrier of the illness. There are three causative genes that have been identified for this type of Alzheimer's disease—APP, PSEN1, and PSEN2 . These genes lead to symptom appearance before 60, and sometimes as early as the 30s or 40s.

Late-onset Alzheimer's disease, on the other hand, involves symptom appearance after the age of 60 . It may be linked to what are called risk genes, the most common of which is the APOE-e4 gene. This gene is related to the formation of amyloid plaques, which has been identified as a possible causative factor of Alzheimer's symptoms. If the APOE-e4 gene is inherited from one parent, the risk of Alzheimer's goes up. If it is inherited from both parents, the risk is even higher. In this case, however, the development of Alzheimer's disease is still not a certainty.