Discuss the most common motor-neuron disease
What will be an ideal response?
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is the most common motor-neuron disease. This incurable condition is characterized by degeneration and eventual death of motor neurons. The result is gradual loss of motor control, progressive paralysis, and finally death within 3 to 5 years of onset. The exact cause is uncertain, although researchers are investigating a variety of potential underlying problems. Among these are pathological changes in neurofilaments that block axonal transport of crucial materials, extracellular accumulation of toxic levels of the excitatory neurotransmitter glutamate, aggregation of misfolded intracellular proteins, mitochondrial dysfunction leading to reduced energy production, and activation of protein-cutting enzymes that selectively cut up the neuronal cell body and nucleus.
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What will be an ideal response
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