A 59-year-old woman with a recent diagnosis of breast cancer has begun a course of hormone therapy. What is the goal of this pharmacologic treatment?
A) Blocking the effects of progesterone on tumor growth
B) Increasing serum hormone levels to promote tumor cell lysis
C) Blocking the entry of malignant cells into the axillary lymph nodes
D) Blocking effects of estrogen on the growth of malignant cells
Ans: D
Feedback:
Hormone therapy is used to block the effects of estrogen on the growth of breast cancer cells. Among the most common drugs used for hormone therapy is tamoxifen, a nonsteroidal antiestrogen that binds to estrogen receptors and blocks the effects of estrogens on the growth of malignant cells in the breast. Such drugs do not directly block axillary node involvement or induce tumor cell lysis.
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