Fluoroquinolones are very effective against both gram-negative and gram-positive organisms. Several of the drugs in this class have been discontinued from use. What adverse effects have caused the removal of these drugs from the market?
1. The development of dysrhythmias after administration of fluoroquinolones
2. The development of pathologic fractures after administration of fluoroquinolones
3. The development of insomnia after administration of fluoroquinolones
4. The development of severe phototoxicity after administration of fluoroquinolones
Correct Answer: 1
Rationale 1: Fluoroquinolones have been indicated as the cause of potentially fatal dysrhythmias after the administration of gatifloxacin and moxifloxacin. These two fluoroquinolones have been removed from the market.
Rationale 2: Fluoroquinolones have caused joint toxicity, and rupture of tendons has been reported. However, this has not caused the removal of fluoroquinolones from the market.
Rationale 3: Fluoroquinolones cause dizziness, headache, and sleep disturbances in a small number of clients. However, this adverse effect has not caused the removal of fluoroquinolones from the market.
Rationale 4: Fluoroquinolones are indicated in the development of moderate-to-severe phototoxicity in clients exposed to direct or indirect sunlight. However, it has not caused the removal of fluoroquinolones from the market.
Global Rationale: Some of the most serious adverse effects of drugs in this class are dysrhythmias (moxifloxacin). Several of the drugs in this class were removed from the market due to the potential for fatal dysrhythmias. Nearly all fluoroquinolones prolong the QT interval. Fluoroquinolones have caused joint toxicity, and rupture of tendons has been reported. However, this has not caused the removal of fluoroquinolones from the market. Fluoroquinolones cause dizziness, headache, and sleep disturbances in a small number of clients. However, this adverse effect has not caused the removal of fluoroquinolones from the market. Fluoroquinolones are indicated in the development of moderate-to-severe phototoxicity in clients exposed to direct or indirect sunlight. However, it has not caused the removal of fluoroquinolones from the market.
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