Which location is the most difficult to reach with antibiotic therapy?
1. Gastrointestinal system
2. Integumentary system
3. Central nervous system
4. Lungs
Correct Answer: 3
Rationale 1: The gastrointestinal system is not a difficult location to reach with antibiotic therapy.
Rationale 2: The integumentary system is not a difficult location to reach with antibiotic therapy.
Rationale 3: The central nervous system is the most difficult location to reach with antibiotic therapy because many medications have difficulty crossing the blood–brain barrier.
Rationale 4: The lungs are not a difficult location to reach with antibiotic therapy.
Global Rationale: Infections of the central nervous system (CNS) are particularly difficult to treat because many medications are unable to cross the blood–brain barrier to reach the brain and associated tissues.
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