Match descriptions of cell-mediated immune responses in questions 1-4, with the appropriate molecule (A-H) from the following list
A. Interferon-?
B. Interleukin (IL)-10
C. IL-12
D. CD40L
E. CD40
F. STAT6
G. STAT4
H. IL-5
This intracellular signaling molecule and transcription factor is activated by IL-12.
ANS: G. Interleukin (IL)-12 binding to its receptors on T cells and natural killer (NK) cells activates the Janus kinase Tyk2, which phosphorylates and activates STAT4. The functional responses of cells to IL-12 are dependent on STAT4-dependent gene transcription. Therefore, TH1 differentiation, which requires IL-12 stimulation of naive T cells, is dependent on STAT4.
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Indicate whether the statement is true or false.
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What will be an ideal response?
Identify the correct translation for the root pneumat/o.
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