A patient presenting a variety of symptoms, including generalized fatigue and neurological impairment, is brought to the hospital, where tests reveal a severe GTP deficiency in the patient’s liver. What is the likely cause of these symptoms?

a. The patient’s cells produce an overabundance of isocitrate, inhibiting GTP production.
b. The patient’s diet contains insufficient quantities of alpha-ketoglutarate.
c. The patient has a mutated form of the enzyme that regulates succinate synthesis.
d. A fat-rich diet caused cholesterol to bond to GTP-precursors, inhibiting GTP production.


c. The patient has a mutated form of the enzyme that regulates succinate synthesis.

Biology & Microbiology

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