In one family, a son was born with polydactyly toes while his sister had polydactyly fingers. In explaining this phenomenon in genetic terms to the parents, which concept should be addressed?
A) Aneuploidy of genes in all cells
B) Deficiencies in enzyme synthesis
C) Heterozygote dominant trait
D) Variable expressivity of a gene
Ans: D
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Autosomal dominant disorders are characterized by variable gene penetrance (degree to which the trait is displayed) and expression (differences in how the trait is displayed). Aneuploidy is not a single-gene disorder and does not follow the Mendelian pattern of inheritance. Deficiencies of enzyme synthesis are common in autosomal recessive disorders. X-linked inheritance can be dominant or recessive, but it is not autosomal.
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