A client who was recently started on the anticoagulant warfarin (Coumadin) asks about adverse reactions. The nurse explains that adverse effects may occur because the drug is highly bound with only ____% available to reach the target cells
Fill in the blank with the appropriate word.
Correct Answer: 1
Rationale: When giving a medication that is highly bound, the nurse should carefully monitor for adverse effects. The anticoagulant warfarin (Coumadin) is highly bound; 99% of the drug in the plasma exists in drug–protein complexes and only 1% exists as a free drug available to reach target cells.
Global Rationale: When giving a medication that is highly bound, the nurse should carefully monitor for adverse effects. The anticoagulant warfarin (Coumadin), is highly bound; 99% of the drug in the plasma exists in drug-protein complexes and only 1% exists as a free drug available to reach target cells.
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