You are interested in Fuzzy, a soluble protein that functions within the ER lumen. Given that information, which of the following statements must be true?
(a) Fuzzy has a C-terminal signal sequence that binds to SRP.
(b) Only one ribosome can be bound to the mRNA encoding Fuzzy during translation.
(c) Fuzzy must contain a hydrophobic stop-transfer sequence.
(d) Once the signal sequence from Fuzzy has been cleaved, the signal peptide will be ejected into the ER membrane and degraded.
Choice (d) is correct. ER signal sequences are typically at the N-terminus [choice (a)]. More than one ribosome can bind to an mRNA molecule [choice (b)]. Hydrophobic stop-transfer sequences are found on membrane-inserted proteins and not on soluble proteins [choice (c)].
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Match the target of the G protein with the appropriate signaling outcome
adenylyl cyclase ________ A. cleavage of inositol phospholipids ion channels _________ B. increase in cAMP levels phospholipase C _________ C. changes in membrane potential Fill in the blank(s) with correct word
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