A patient is receiving a combination of cyclophosphamide, doxorubicin, and 5-fluorouracil for the treatment of breast cancer given every 4 weeks. The patient's tumor is responding well, but the patient is complaining of swelling of the ankles and shortness of breath. Congestive heart failure is confirmed by ultrasound. Considering the toxicity profiles, what change in therapy would you recommend in this setting?
A. Replace 5-fluorouracil with methotrexate
B. Replace doxorubicin with mitoxantrone
C. Replace cyclophosphamide with cisplatin
D. Add leucovorin to the treatment regimen
E. Discontinue cyclophosphamide
Ans: B. Replace doxorubicin with mitoxantrone
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