Why would animals prescribed phenobarbital for seizure control need to have blood collected to determine phenobarbital blood levels about three to six weeks after starting treatment?
What will be an ideal response?
Phenobarbital is a drug that induces liver enzymes, which can speed the metabolism of phenobarbital (and other drugs).
With the induction of liver enzymes, the animal's body becomes more efficient at removing phenobarbital, thereby allowing phenobarbital concentrations to drop below the therapeutic range. When phenobarbital concentrations fall below the therapeutic range, seizures may reoccur. Therefore, accurate assessment of blood phenobarbital levels allows for more successful treatment.
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