Describe the actions and give examples of Alzheimer's drugs.
What will be an ideal response?
Answers will vary.
Treatment for Alzheimer's disease focuses on cholinesterase inhibitors such as donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), which are responsible for the breakdown of acetylcholine in the synaptic cleft. Memantine (Namenda) is an N-methyl-D-aspartate (NMDA) receptor antagonist in which NMDA receptors are activated in the brain by glutamate, an excitatory amino acid. It is used in the treatment of moderate to severe Alzheimer's disease.
Other drugs have been useful in the treatment of Alzheimer's disease. Antidepressants such as sertraline (Zoloft), fluoxetine (Prozac), amitriptyline, and nortriptyline and antipsychotics such as loxapine (Loxitane), haloperidol, risperidone (Risperdal), olanzapine (Zyprexa), and quetiapine (Seroquel) may be used to alleviate manifestations. Zolpidem (Ambien) may also be prescribed for sleep disturbances.
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