Compare and contrast the arteriovenous difference technique with isotopic approaches


The arteriovenous difference technique is relatively invasive, requiring simultaneous sampling of arterial and venous blood, and measurement of blood flow through the region of interest. The difference in substrate levels between the arterial blood and venous blood represents the production or release of that substrate.

Isotopes of a given element have identical chemical properties but slightly different physical properties, which allow them to be distinguished analytically from their common form. This allows researchers to trace the inflow and outflow of a substrate or metabolite from the vascular space, and to follow the conversion of a substrate through its metabolic pathway into an end-product.

Health & Biomechanics

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Health & Biomechanics