Explain the kiss-and-run model of synaptic vesicle exocytosis, and how it differs from the classic model.

What will be an ideal response?


With the kiss-and-run model the synaptic vesicles fuse to the presynaptic membrane at a fusion complex. When the neurotransmitter is released through the fusion complex into the synaptic cleft the vesicles then pull away from the complex and re -enter the vesicle pool in the cytoplasm. With the classical model the vesicle becomes incorporated into or becomes part of the cell membrane.

Anatomy & Physiology

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