The antibiotic valproic acid (Depakote) is an inhibitor of biotransformation. How will this affect the pharmacokinetics of this medication?

a. The ionization of Depakote will slow its absorption.
b. The reduction of CP450 function leaves more active drug in the body.
c. Depakote metabolites are excreted more in the bile than in the urine.
d. The binding of Depakote to blood proteins reduces the activity of the drug.


b

Nutritional Science

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