Which statement about patients with Parkinson's disease (PD) accurately describes when anti-cholinergic drugs are most useful in treating them?
a. The patient is early in the course of the disease, with tremor but with little rigidity or bradykinesia.
b. The patient has moderate tremor and rigidity accompanied by drooling.
c. The patient is late in the course of the disease, with many symptoms.
d. The patient is an older adult and is unable to tolerate dopaminergic drugs.
ANS: A
Anticholinergics are useful early in younger patients with PD, more to control tremor by relaxing smooth muscle than for treatment of the other manifestations of the disease. Anticholinergics are also a reasonable treatment option for middle-aged adults who have tremor but little rigidity or bradykinesia.
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