Which of the following genes may attribute to the virulence of H. pylori by encoding for outer membrane proteins that mediate adherence to a specific blood group antigen on the surface of gastric epithelial cells?

a. babA
b. iceA
c. cagA
d. vacA


A
babA encodes outer membrane proteins and mediates adherence to blood group antigens on the surface of gastric epithelial cells. The presence of iceA is associated with peptic ulcer disease in some populations; cagA encodes a type IV secretion system for transferring cagA proteins into host cells; and vacA creates vacuoles in epithelial cells, decreases apoptosis, and loosens cell junctions.

Biology & Microbiology

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