Huntington's disease (HD) is a fatal neurological disease that is inherited in an autosomal dominant manner. Most people with HD develop signs and symptoms in their late 30s or early 40s, but the onset of disease may be earlier or later in life. A 20-year-old woman comes to your genetic counseling center because she knows that HD occurs in members of her family. Her paternal grandfather was afflicted, but so far her 41-year-old father shows no symptoms. Her two great-great grandmothers on her father's side were healthy well into their 90s, and one of her great-great grandfathers died of unknown causes at 50. Testing for HD is extremely expensive, but she is concerned that she may fall victim to this disease and wants to plan her life accordingly. After examining her pedigree you advise
her to
A. not get tested because only males in her family get the disease.
B. get tested because there is no possibility that she does not carry the HD allele.
C. not get tested because her father is at worst, heterozygous for the HD allele.
D. get tested because her father could be heterozygous for the HD allele.
E. not get tested because her father shows no symptoms.
Answer: D
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