When administering medications, which concept pertaining to the blood-brain barrier must the nurse understand?
A) Highly lipophilic medications cross the blood-brain barrier directly.
B) Highly lipophilic medications cannot cross the blood-brain barrier.
C) Highly lipophilic medications cross the blood-brain barrier by simple diffusion.
D) Highly lipophilic medications cross into the brain where there is no blood-brain barrier.
A) Highly lipophilic medications cross the blood-brain barrier directly.
Explanation: A) Highly lipophilic substances are able to cross the membrane directly and enter the brain, and water can cross the membrane by simple diffusion. Most nutrients cross the barrier by facilitated diffusion through mechanisms that couple the movement of the nutrient with movement of an ion that is moving down its concentration gradient.
B) Highly lipophilic substances are able to cross the membrane directly and enter the brain, and water can cross the membrane by simple diffusion. Most nutrients cross the barrier by facilitated diffusion through mechanisms that couple the movement of the nutrient with movement of an ion that is moving down its concentration gradient.
C) Highly lipophilic substances are able to cross the membrane directly and enter the brain, and water can cross the membrane by simple diffusion. Most nutrients cross the barrier by facilitated diffusion through mechanisms that couple the movement of the nutrient with movement of an ion that is moving down its concentration gradient.
D) Highly lipophilic substances are able to cross the membrane directly and enter the brain, and water can cross the membrane by simple diffusion. Most nutrients cross the barrier by facilitated diffusion through mechanisms that couple the movement of the nutrient with movement of an ion that is moving down its concentration gradient.
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