The overall error rate in translation is low, approximately one wrong amino acid for every 104 or 105 incorporated. What stages in tranlsation can introduce errors and which of these is the weak point in translation?
What will be an ideal response?
Ans: A wrong base can be incorporated into the mRNA, the aminoacyl-tRNA synthetase can bind either the wrong amino acid or wrong tRNA, a ribosomal frameshift may occur during translocation or the wrong aminoacyl-tRNA can enter the A site. The weak point (5 × 10-4 error rate) in translation is when the ribosome allows the wrong aminoacyl-tRNA to enter the A site resulting in the wrong amino acid being incorporated into the polypeptide. This error rate is due to the small number of interactions between the three base pairs between the mRNA codon and the tRNA anticodon.
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