Patients who have type 2 diabetes no longer respond normally to insulin. Which statement best explains this symptom?
A. The signal transduction pathways in the cells no longer exist.
B. The nucleus of their cells are altered so that insulin can not bind.
C. Type 2 diabetics do not produce insulin.
D. The insulin receptors on their cells have mutated.
E. Their cells express less insulin receptor.
Answer: E
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