Which of the following are functions of the spleen in a healthy adult? (Select all that apply.)
a. Storage of platelets
b. Production of red blood cells
c. Phagocytosis of worn blood cells and platelets
d. Formation of bilirubin
e. Production of lymphocytes and monocytes
f. Production of neutrophils and eosinophils
ANS: A, C, D, E
The spleen contains B cells and T lymphocytes, which mediate immune responses. It also contains fixed macrophages that phagocytize pathogens and worn or defective blood cells and platelets. The heme unit from red blood cell destruction forms bilirubin. Bilirubin is sent to the liver by way of portal circulation for excretion in the bile. The spleen also stores up to one-third of the body's platelets. Red blood cells are produced in the bone marrow, not the spleen. Neutrophils and eosinophils are produced in the red bone marrow, not in the spleen.
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