If you remove the ERretention signal from a protein that normally resides in the ER lumen, where do you predict the protein will ultimately end up? Explain your reasoning
What will be an ideal response?
The protein would end up in the extracellular space. Normally, the protein would go from the ER to the Golgi apparatus, get captured because of its ERretention signal, and return to the ER. However, without the ERretention signal, the protein would evade capture, ultimately leave the Golgi via the default pathway, and become secreted into the extracellular space. The protein would not be retained anywhere else along the secretory pathway: it presumably has no signals to promote such localization because it normally resides in the ER lumen.
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