What would you expect to see on microscopic examination of a stained blood smear if the patient has had a splenectomy and why?
What will be an ideal response?
Answer: You would expect to see erythrocyte inclusions such as Howell-Jolly bodies and Pappenheimer bodies and in some cases abnormal erythrocyte shapes. This is because the spleen is responsible for pitting inclusions from RBCs and culling abnormal RBCs. The liver can remove some of these abnormal cells but is not as effective as the spleen in doing so.
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