A patient who is taking olanzepine (Zyprexa) also smokes. Which will the nurse include when discussing use of Zyprexa with this patient?
1. Smoking can diminish the effect of Zypreza.
2. Zyprexa will increase the negative effects of smoking.
3. Smoking can increase the possible toxicity of Zyprexa.
4. Smoking is bad for the patient's health but will not interact with Zyprexa.
Answer: 1
Explanation: Cigarette smoking is an inducer of CYP 1A2 and can diminish the effect of Zyprexa. Smoking does not increase the toxicity of Zyprexa, nor does Zyprexa increase the negative effects of smoking. Smoking does interact with Zyprexa.
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