A nurse would monitor a client receiving a cholinergic blocking drug for an increased effect when the drug is administered with which of the following? Select all that apply
A) Fluconazole (Diflucan)
B) Meperidine (Demerol)
C) Haloperidol (Haldol)
D) Amitriptyline (Elavil)
E) Digoxin (Lanoxin)
Ans: B, D
Feedback:
A nurse may notice an increased effect of the cholinergic blocking drug when it is administered with meperidine (Demerol) and amitriptyline (Elavil) because meperidine and tricyclic antidepressants increase the effect of the cholinergic blockers. If given with fluconazole, an antifungal agent, the effectiveness of the antifungal agent decreases. If given with haloperidol, haloperidol's effectiveness is decreased. If given with digoxin, the risk for digoxin toxicity increases.
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