Angiotensin-converting enzyme (ACE) inhibitor drugs function in the control of blood pressure by which mechanism of action?
1. Blocking the effects of angiotensin II
2. Blocking the conversion of angiotensin I to angiotensin II
3. Blocking the conversion of angiotensin II to angiotensinogen
4. Directly inhibiting renin
Correct Answer: 2
Rationale 1: ACE inhibitors do not block the effects of angiotensin II, but of angiotensin I.
Rationale 2: ACE inhibitors prevent conversion of angiotensin I to angiotensin II.
Rationale 3: Angiotensin II does not convert to angiotensinogen.
Rationale 4: ACE inhibitors do not block renin.
Global Rationale: ACE inhibitors prevent conversion of angiotensin I to angiotensin II which controls blood pressure. ACE inhibitors do not block the effects of angiotensin II. Angiotensin II does not convert to angiotensinogen. ACE inhibitors do not block renin.
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