The nurse tells a client that, due to leptin secretion by adipocytes, the hypothalamus has what affect on appetite?
1. Intensification of appetite
2. Maintenance of appetite
3. Decrease of appetite
4. Inappropriate appetite
Correct Answer: 3
Rationale 1: Intensifying of the appetite is not due to the binding of leptin.
Rationale 2: The binding of leptin does not maintain appetite.
Rationale 3: The binding of leptin signals the hypothalamus to decrease appetite.
Rationale 4: The binding of leptin does not cause inappropriate appetite as is seen with PICA.
Global Rationale: A hormone that regulates hunger and weight balance is leptin, a protein secreted by adipocytes (fat cells). When a certain amount of fat has been stored, adipocytes increase their secretion of leptin. Receptors for leptin are located in the satiety center in the hypothalamus. Binding of leptin to its receptors signals the hypothalamus that the body has ingested enough food and tells the brain how much adipose tissue is present.
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