The major difference in adverse effect profile between ACE inhibitors and ARBs is that ARBs do not cause which clinical manifestation?
1. Headache
2. Dizziness
3. Angioedema
4. Cough
Correct Answer: 4
Rationale 1: ARBs can cause headaches, as can ACE inhibitors.
Rationale 2: ARBs can cause dizziness, as can ACE inhibitors.
Rationale 3: There is a risk of angioedema with ARB therapy, but it is less than that with ACE inhibitor therapy.
Rationale 4: Since ARBs do not promote accumulation of bradykinin, they do not cause a cough.
Global Rationale: Since ARBs do not promote accumulation of bradykinin, they do not cause a cough. ARBs and ACE inhibitors both can cause headaches and dizziness. There is a risk of angioedema with ARB therapy, but it is less than that with ACE inhibitor therapy.
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