Which statement is correct regarding the effectiveness of thiazides in relation to glomerular filtration rate (GFR)?
1. Thiazides are ineffective if GFR is less than 15-20 ml/min.
2. Thiazides are ineffective if GFR is more than 50 ml/min.
3. Thiazides are not dependent on GFR.
4. Thiazides and GFR are directly related in terms of effectiveness.
Correct Answer: 1
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