Alpha-1 antitrypsin deficiency should be considered in patients diagnosed with:
A. Exercise-induced cough
B. Bronciectasis
C. COPD
D. Pericarditis
ANS: C
When younger patients or nonsmokers develop findings consistent with COPD, alpha-1 antitrypsin deficiency should be suspected. Currently, the American Thoracic Society (2003) recommends that all individuals with COPD or asthma with chronic obstructive changes be tested for alpha-1 antitrypsin deficiency. If alpha-1 antitrypsin deficit is suspected, a qualitative serum should be performed as a screen, followed by quantitative study, as indicated.
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