A 60-year-old chronic smoker was found to have a small-cell carcinoma of the lung
During the laboratory work-up it was found that he had low serum natrium, low serum osmolality, but normal extracellular fluid volume.
Urine osmolality and concentration of sodium in urine were high. These findings are most consistent with a paraneoplastic syndrome caused by an oversecretion of
A. adrenocorticotropic hormone
B. antidiuretic hormone (ADH)
C. atrial natriuretic hormone
D. parathyroid hormone
E. parathyroid hormone–related protein
B
Hyponatremia and low serum osmolality in the presence of high urinary osmolality and sodium excretion are features of the syndrome of inappropriate ADH secretion (SIADH). ADH is usually released from small-cell carcinoma of the lung.
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The progressive deterioration of the retinal cells in the macula due to aging is ____________________ ____________________
Fill in the blank(s) with correct word