A quantitative sweat chloride test has been done on an 8-month-old child. What value should be indicative of cystic fibrosis (CF)?
a. Less than 18 mEq/L
b. 18 to 40 mEq/L
c. 40 to 60 mEq/L
d. Greater than 60 mEq/L
ANS: D
Normally sweat chloride content is less than 40 mEq/L, with a mean of 18 mEq/L. A chloride concentration greater than 60 mEq/L is diagnostic of CF; in infants younger than 3 months, a sweat chloride concentration greater than 40 mEq/L is highly suggestive of CF.
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