What is the essential difference in response of these two cell types when antigen binds to these surface immunoglobulins

What will be an ideal response?


(i) The immunoglobulin on a mast cell is an IgE antibody that has become bound to the mast cell's FcεRI receptor, whereas the immunoglobulin on a B cell is a transmembrane form made by the cell itself. (ii) A B cell might have any class of immunoglobulin on its surface, whereas mast cells have only IgE. (iii) IgE molecules of many different antigen specificities can be bound to the surface of an individual mast cell, whereas an individual B cell carries immunoglobulin molecules of only one specificity.After binding to antigen, mast cells become operational as effector cells without the need to undergo proliferation or differentiation. In contrast, after antigen binds to a surface immunoglobulin on a B cell, the cell must proliferate and differentiate to produce effector cells (antibody-secreting plasma cells).

Health & Biomechanics

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