A dish of cells is treated with centrinone, a centriole inhibitor. These cells would no longer be able to ___.

Question

A.  conduct photosynthesis
B.  synthesize proteins
C.  make ATP
D.  produce lysosomes
E.  divide

Clarify Question
· What is the key concept addressed by the question?
· What type of thinking is required?
· What key words does the question contain and what do they mean?
 
Gather Content
· What do you know about centrioles? How does it relate to the question?

Consider Possibilities
· What other information is related to the question? Which information is most useful?

Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?

Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?

Answer 1

E.  divide

Clarify Question
· What is the key concept addressed by the question?
        o The question asks about centrioles.
· What type of thinking is required?
        o You are being asked to apply your knowledge of the function of a centriole to predict what would happen to a cell if the centrioles were inhibited.
· What key words does the question contain and what do they mean?
        o Centrinone inhibitor – This chemical was added to cells to block the activity of the centrioles
 
Gather Content
· What do you know about centrioles? How does it relate to the question?
        o Centrioles are found in the nucleus and they organize the microtubules that bind to chromosomes during cell division in mitosis or meiosis.

Consider Possibilities
· What other information is related to the question? Which information is most useful?
        o The drug centrinone does not affect other structures in the cell that are involved in protein synthesis, photosynthesis or ATP production.

Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
        o Centrioles are involved in forming the spindles from the edges of the nucleus to chromosomes.  These microtubule spindles then pull the chromosomes to separate ends of the cell during mitosis, an essential step in cell division.  If the centrioles are inhibited then the cells cannot divide.

Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
        o This question asked you to apply the function of centrioles to predict what would happen to cells in which centriole activity was blocked. If you got the correct answer, great job! If you got an incorrect answer, where did the process break down? Did you recall the function of centrioles?  Could you predict what would happen if centriole activity was blocked?  Did you think that centrioles had one of the other functions listed?