A nurse performing an admission history on a patient learns that the patient is taking orlistat (Xenical), warfarin (Coumadin), and levothyroxine (Synthroid). What will the nurse do?

a. Contact the provider to discuss increasing the warfarin dose.
b. Give the levothyroxine at least 4 hours before giving the orlistat.
c. Suggest that the patient avoid fatty foods while taking these medications.
d. Tell the patient to take the orlistat on an empty stomach.


ANS: B
Orlistat may cause hypothyroidism in patients taking levothyroxine; these two drugs should be administered at least 4 hours apart. The vitamin K deficiency that can occur with orlistat may compound the effects of warfarin, so coagulation should be monitored; it is more likely that the warfarin dose would need to be reduced. The patient may still consume foods containing fat, as long as fat accounts for about 30% of the total intake. Orlistat should be taken with food.

Nursing

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