A nurse is explaining drug metabolism to a nursing student who asks about glucuronidation. The nurse knows that this is a process that allows drugs to be:
a. excreted in hydrolyzed form in the feces to reduce drug toxicity.
b. reabsorbed from the urine into the renal circulation to minimize drug loss.
c. recycled via the enterohepatic recirculation to remain in the body longer.
d. transported across the renal tubules to be excreted in the urine.
C
Glucuronidation of some drugs in the liver allows drugs to enter the bile, pass into the duodenum, and then be hydrolyzed to release the free drug. This is a repeating cycle of enterohepatic recir-culation, which allows drugs to remain in the body longer. Glucuronidated drugs that are more resistant to hydrolysis are excreted in the feces. Glucuronidation occurs in the enterohepatic cir-culation and not in the renal circulation.
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After orientation, you will be evaluated on your skills and abilities
True False