A patient is taking phenazopyridine (Azo-Standard) and ciprofloxacin (Cipro) for a urinary tract infection. What is the most important instruction the nurse needs to provide to the patient concerning this drug combination?
A) "Do not be alarmed if your urine is a reddish-brown color."
B) "Be sure to take your medication with food if you have GI irritation."
C) "Increase your fluid intake. Drink lots of water."
D) "If you notice yellowing of your eyes or skin, contact your health care provider immediately."
D
Feedback:
Yellowing of the sclera and skin is a sign of drug accumulation in the body and a possible sign of hepatic (liver) toxicity. Phenazopyridine should not be used more than 2 days, especially if taken, as here, with an antibacterial agent (ciprofloxacin). The other suggested options are important and should be included in the instructions given the patient. However, the possibility of toxicity is the most important.
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