A patient with colorectal cancer is admitted to the hospital oncology unit to receive cetuximab (Erbitux). The nurse notes that the prescriber has not ordered any other medications
The nurse will contact the prescriber to request an order for which medication in order to minimize cetuximab's side effects?
a. Diphenhydramine (Benadryl)
b. Epinephrine
c. Ondansetron (Zofran)
d. Magnesium supplements
ANS: A
Cetuximab can cause severe infusion reactions. Premedication with diphenhydramine can help reduce this risk. Epinephrine is used for medical management of an infusion reaction and not to minimize the risk. Ondansetron is not indicated because nausea and vomiting are not a concern. Magnesium supplements are given when hypomagnesemia is documented, not as a preventive.
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