Probenecid is sometimes given to patients taking penicillin to prolong the penicillin half-life and thus enhance plasma levels of penicillin. This is a desirable example of which effect?
a. Additive effect
b. Antagonistic effect
c. Synergistic effect
d. Drug interaction
ANS: D
Some medications are given together on purpose because the drug interactions are helpful. Probenecid is given with penicillin to elevate and prolong the blood levels of penicillin. Probenecid does this by blocking penicillin's elimination pathway via the kidneys (by inhibiting renal tubular secretion). Maintaining high blood levels of penicillin is important in treating venereal disease.
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