Indicate which of the following statements is false. (Select all that apply.)
a. Immunoglobulin heavy- and light-chain loci are encoded on the same chromosome.
b. Light chains contain V and J segments, whereas heavy chains contain V, D, and J segments.
c. The V? gene segments are duplicated in about 50% of the human population.
d. All immunoglobulin loci include a leader sequence.
e. On the heavy-chain locus, V rearranges to D first, and then J joins the combined VD sequence.
f. Immunoglobulin heavy-chain loci undergo two rounds of somatic recombination, whereas light-chain loci undergo only one.
A,E
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