Which of these would the nurse recognize as a therapeutic prothrombin time (PT) value for a patient on warfarin (Coumadin) when the laboratory's normal prothrombin time range is 9 to 11 seconds?
a. 12.5 seconds
b. 17 seconds
c. 30 seconds
d. 26 seconds
ANS: B
Warfarin's therapeutic range is 1.5 to 2 times the normal prothrombin time range. To monitor the patient's therapeutic prothrombin time, compare the patient's result with the therapeutic range. The therapeutic range is 13.5 to 22 seconds, so B is correct. A is subtherapeutic. C and D are above therapeutic.
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In a nonequivalent-control-group design, the most serious threat to internal validity is:
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