Which of the following patients would be at the highest risk for aminoglycoside-induced nephrotoxicity?
a. A 26-year-old woman with persistent headaches and tinnitus
b. A 26-year-old female newlywed with chronic UTIs
c. A 72-year-old patient also taking amphotericin B (Fungizone)
d. A 30-year-old patient with pyelonephritis
ANS: C
The risk of renal damage is increased by concurrent therapy with other nephrotoxic agents, such as amphotericin B, cephalosporins, vancomycin, and aspirin.
This patient should be monitored for ototoxicity.
The patients with UTI and pyelonephritis are not at risk for nephrotoxicity, because nothing indicates kidney damage.
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