You are studying the function of a recently identified gene in C. elegans. You perform genetic screens for several months in an attempt to isolate loss-of-function gene mutations, but your efforts are unsuccessful. Your advisor suggests you try another approach to eliminate gene function. The best technique to accomplish this goal would be

A. use RNA interference to prevent mRNA translation.
B. use a histone deacetylase to induce a transcriptionally inactive state.
C. to design a repressor to bind to the operon of this gene.
D. use a C. elegans strain with a homozygous TFIID mutation to prevent the translation initiation complex from forming.


Answer: A

Biology & Microbiology

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