Which effector T cells are usually involved in this reaction, and why?
What will be an ideal response?
CD8 cytotoxic T cells. The proteins that act as minor histocompatibility antigens are mainly intracellular proteins. Intracellular proteins of the recipient's cells are processed into peptides by proteasomes as part of normal protein degradation and turnover. These peptides are transported into the endoplasmic reticulum and thus are eventually presented on the surface of the recipient's cells by HLA class I molecules. Any peptides that are different from those in the donor may be recognized as non-self by the donor's cytotoxic T cells, which recognize peptides bound to HLA class I molecules. The naive CD8 T cells in the bone marrow can be activated to effector status by the presentation of minor histocompatibility peptides by dendritic cells in secondary lymphoid organs.
Because the brother and sister share HLA class I type, the sister's T cells will be able to recognize non-self peptides presented by her brother's HLA molecules.
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The mission of a professional health organization is to assist government and quasi-governmental health agencies
Indicate whether the statement is true or false.