A patient with chronic skeletal muscle spasms was placed on an anticholinergic medication
After taking the medication, the patient's muscle spasms ceased, but now the patient reports a loss of muscle strength. In addition, the patient's resting heart rate has increased. Explain the effects of the medication the patient received.
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Medications that block the action of acetylcholine are described as anticholinergic. Since ACh stimulates skeletal muscles to contract, blocking ACh should help reduce muscle spasms. In high enough doses, the medication might prevent the normal contraction of skeletal muscles and could, perhaps, cause a flaccid paralysis. Heart rate increases because ACh usually slows heart rate so a drug that blocks ACh's effect would lead to increased heart rate. Perhaps a medication that specifically blocked nicotinic receptors would eliminate the muscle spasms without causing increased heart rate.
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