Which of the following explains why TSH levels are elevated with hypothyroidism?
A. There is a positive feedback to the pituitary gland, increasing TSH.
B. The hypothalamus decreases TRH release when thyroid hormone levels are low.
C. The low level of thyroid hormones inhibits negative feedback to the thyroid gland.
D. The anterior pituitary does not receive feedback from the hypothalamus, thus increasing TSH levels.
Answer: C
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