What might happen on a postsynaptic neuron if, at the same time, it receives one stimulus at an excitatory synapse located close to the axon hillock but receives two stimuli at two different inhibitory synapses, both of which are far away from the axon hillock?
What will be an ideal response?
Since graded potentials diminish in intensity as they travel across a membrane, the closer to the axon hillock the stimulus is applied, the greater its effect. Therefore, one excitatory stimulus generating an EPSP near the axon hillock may be intense enough to reach threshold and initiate an action potential on the postsynaptic neuron, because the two IPSPs generated by the inhibitory neurons diminish as they move toward the axon hillock and may not be able to counteract the one EPSP generated near the hillock.
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